Over the past few decades, accumulating evidence has highlighted the various roles of melatonin in human physiology and health conditions. Melatonin is now recognized not just as a hormone but also as a cell protector. Research has revealed its significant impact on various pathways such as oxidative stress, immune modulation, and hematopoiesis. Additionally, numerous studies have demonstrated melatonin’s anticancer properties, acting through diverse mechanisms. Furthermore, melatonin has been employed in combination with other cancer therapies to enhance the effectiveness of conventional treatments and minimize their side effects.

This 2021 Medical Publication pretty much says it all about Melatonin and its Anti-Cancer benefits:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278/

Published online 2021 Apr 25. doi: 10.3390/molecules26092506

PMCID: PMC8123278

PMID: 33923028

Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

Wamidh H. Talib,^1,* Ahmad Riyad Alsayed,¹ Alaa Abuawad,² Safa Daoud,³ and Asma Ismail Mahmod¹

Dun-Xian Tan, Academic Editor

Here is the Conclusion:

“The role of melatonin in cancer treatment and prevention have been widely studied and numerous experimental studies proved the anticancer effect of melatonin against many cancers, including colorectal, breast, gastric, prostate. ovarian, lung, and oral. The anticancer effect of melatonin is mediated by integrated mechanisms, such as apoptosis induction, immune system modulation, targeting cancer altered mechanism, angiogenesis inhibition, and antimetastatic effect. Combination of melatonin with conventional anticancer therapies showed positive results through reinforcing the therapeutic effects of these therapies. Clinically, melatonin was active to augment the therapeutic effects of anticancer drugs and improve the sleep and life quality of cancer patients. Several clinical studies have suggested that the efficiency of chemotherapy can be enhanced when melatonin was incorporated. The therapeutic effect of melatonin increases when combined with other anticancer agents. Studies showed that the melatonin anticancer effect is not tissue specific and its therapeutic and preventive properties were reported in cancer arising from different tissues. Melatonin can be obtained from plants as phytomelatonin. Its levels vary according to plant species and plant parts. However, the highest level was found in seeds. Bioavailability and pharmacokinetic properties of exogenous melatonin are still not fully understood. High variability in bioavailability was reported with values ranging from 1 to 100%. Such variable numbers are mainly due to remarkable inter-individual variations in all pharmacokinetic aspects including absorption, metabolism, and elimination. Bioavailability of melatonin deserves further studies to clearly understand the interindividual differences. Overall, the low toxicity, diverse mechanisms of action, and high efficiency of melatonin support its use in cancer prevention and treatment.”

Other Articles of relevance:

1. https://www.oncotarget.com/article/16379/text/ Melatonin for the prevention and treatment of cancer Li Y., Li S., Zhou Y., Meng X., Zhang J., Xu D., Li H. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017; 8: 39896-39921. Retrieved from https://www.oncotarget.com/article/16379/text/
2. https://ar.iiarjournals.org/content/32/7/2747 Role of Melatonin in Cancer Treatment ANTONIO CUTANDO, ANTONIO LÓPEZ-VALVERDE, SALVADOR ARIAS-SANTIAGO, JOAQUIN DE VICENTE and RAFAEL GÓMEZ DE DIEGO, Anticancer Research July 2012, 32 (7) 2747-2753;
3. https://www.dovepress.com/role-and-therapeutic-potential-of-melatonin-in-various-type-of-cancers-peer-reviewed-fulltext-article-OTT Role and Therapeutic Potential of Melatonin in Various Type of Cancers. “There is a large body of evidence from experimental and clinical studies suggesting that MLT has the potential to exhibit anticancer activities, such as apoptotic, oncostatic, anti-proliferative, and antiangiogenic effects, against all solid and liquid tumors. MLT mitigates cancer at the initiation, progression, and metastasis phases. “
4. https://www.explorationpub.com/Journals/em/Article/100178. The potential anti-cancer effects of melatonin on breast cancer. Melatonin acts as a potent anti-cancer agent. The actions of melatonin in breast cancer are driven by regulating the different molecular pathways related to growth inhibition and pro-apoptotic effects. Exposure to LAN, shift/might work, chronic jet lag, and sleep disorder hamper melatonin synthesis and lower the night-time melatonin peak. 

Social Media Groups:

Instructions on How to Request to Join Facebook Groups:

These Groups are all Private Groups, which means that you have to request to “Join”. Joining these groups is a Crucial step to speaking to Survivors. Here are the Steps to Joining a group and starting to communicate and get information:

1. Click on the Link and Make sure you are signed into Facebook
2. Click Request to Join-You will then get a list of Questions that the Group Admin designs. These are designed to make sure you are real and have personal interest in Joining the group.
3. Fill out ALL the questions that are asked. Be Sincere and Honest. You are looking for Help for you or a loved one and tell them that.
4. You will be approved almost all the time if you are real and sincere. Approval could be instant or take up to a few days. It all depends on the Group Admins and Group membership settings

Instructions on what to do When you are Accepted to Join Facebook Groups:

Once accepted to the Group you will receive a Notification that Admins have approved your request to Join! Here are the next steps to getting integrated into the group and getting information.

1. Go to the Group homepage. Get familiar with the pages within the group. There is often very valuable information and documents uploaded and available here. For example: Discussion, Featured, Events, Media, Files..
2. Reach out to the Group Admin and introduce yourself. Find the admin on the “Members” page. The message should introduce yourself, thank them for allowing you into the group and briefly explain your situation and ask for guidance. The often are very knowledgeable on Alternative Treatments.
3. Post your first post into the group. Be honest and sincere and ask for help. Tell about your situation and journey and ask for Advice. Don’t be afraid to ask for Success Stories. They are there and the Survivors are very willing to help and give advice.
4. Use the Search bar )Magnifying Glass” to search fro prior posts and chats that may be useful to you. Search your type of Cancer, search for specific treatment types, search for Success stories. Sort by most recent.