Studies/Publications
- Deuterium Depletion May Delay the Progression of Prostate Cancer
Deuterium-depleted water (DDW) is a new promising agent in cancer therapy. The efficiency of the method is based on the discovery, that cancer cells are extremely sensitive to depletion of deuterium (D) and might cause necrosis of the tumour.
2. A Preliminary Study Indicating Improvement in the Median Survival Time of Glioblastoma Multiforme Patients by the Application of Deuterium Depletion in Combination with Conventional Therapy
Deuterium depletion substantially prolonged the survival time of GBM patients in an advanced stage. We conclude that D depletion offers additional benefits to conventional therapies and has a significant role in delaying progression. Application of DDW is recommended in all stages of the disease before surgery, parallel to radiotherapy and chemotherapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377426/
3. Anticancer Effect of Deuterium Depleted Water – Redox Disbalance Leads to Oxidative Stress*
Our experiments confirmed the effect of deuterium depletion on cancer cell growth. The novel aspect is the suggested molecular mechanism supporting the anticancer effect of DDW. Our results indicate that DDW inhibits cell proliferation mainly through causing a disbalance between ROS production and neutralization in mitochondria, and thus inducing oxidative stress in the cells.
https://www.sciencedirect.com/science/article/pii/S1535947620316431
4. Glyphosate, Deuterium and COVID-19
https://www.faim.org/glyphosate-deuterium-and-covid-19
5. Effect of Deuterium Depletion on Erythrocytes in Experimental Diabetes
In conclusion, deuterium depletion may have protective effects on diabetes induced oxidative stress. Further studies are needed to be done to determine the mechanism of action and the useful dosage and the application period of DDW.
https://doi.org/10.26650/experimed.2020.0007
6. Blocking the Increase of Intracellular Deuterium Concentration Prevents the Expression of Cancer-Related Genes, Tumor Development, and Tumor Recurrence in Cancer Patients
So, deuterium depletion opens new perspectives in cancer treatment and prevention, offering a completely safe and non-invasive treatment modality.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777325/
7. Effects of the Intake of Deuterium Depleted Water During Cancer Therapy: A Narrative Review-
As conclusions of this review, it is highlighted that the intake of DDW has beneficial effects such as: the increase in the average survival time of cancer patients, the inhibition of the growth of cancer cells, the total or partial regression of malignant tumors, delay in the multiplication of various types of tumor cells (PC-3, MDA, HT-29 and M14) and decrease in PSA values in patients with prostate cancer. The number of studies carried out with DDW are very scarce in the scientific literature, so more studies are needed on the influence of DDW intake during the treatment and prevention of cancer.
8. Deuterium Depletion Inhibits Cell Proliferation, RNA and Nuclear Membrane Turnover to Enhance Survival in Pancreatic Cancer
In vitro growth inhibition by deuterium-depleted water (DDW) alone or in combination with cisplatin in MIA PaCa-2 pancreatic cancer cells
https://journals.sagepub.com/doi/10.1177/1073274821999655
9. Deuterium Depleted Water Inhibits the Proliferation of Human MCF7 Breast Cancer Cell Lines by Inducing Cell Cycle Arrest
DDW exerts effects on the cell cycle, changes in cell configuration and induces antioxidant enzymes in vitro. DDW can be considered as an adjuvant to conventional anticancer agents in future trials.
https://pubmed.ncbi.nlm.nih.gov/31045450/
10. Time-Dependent Effect Of Deuterium Depletion On Tumor Growth And Metastasis
In conclusion, our findings demonstrate that deuterium depletion exerts antitumor effect by inhibiting both tumor growth and metastasis. But development of antitumor effect requires preliminary depletion of deuterium content. It indicates that antitumor effect depends not only on degree of deuterium depletion. A complex of physiological changes, produced by deuterium depletion, is probably also mediated attenuation of tumor growth. Alteration of physiological parameters requires certain period of time to develop that is why only preliminary deuterium depletion demonstrated antitumor effect.
11. Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis
Our in vivo results revealed that DDW significantly inhibited tumor growth. However, we do not know whether the effect was caused by cell apoptosis. Further studies are needed to elucidate the mechanism of DDW-induced tumor inhibition in vivo.
In summary, we found that DDW exerts effects on the cell cycle and changes in configuration and induces apoptosis in vitro. We also found that DDW inhibits tumor growth in xenotransplanted mice. Collectively, these findings suggest the potential for DDW as an anti-tumor drug with clinical application.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445928/
12.A retrospective evaluation of the effects of deuterium depleted water consumption on 4 patients with brain metastases from lung cancer
Conclusions: DDW was administered as an oral anticancer agent in addition to conventional therapy, and noticeably prolonged the survival time of all 4 lung cancer patients with brain metastasis. We suggest that DDW treatment, when integrated into other forms of cancer treatment, might provide a new therapeutic option.
https://pubmed.ncbi.nlm.nih.gov/18815148/
13. Deuterium Depletion Inhibits Cell Proliferation, RNA and Nuclear Membrane Turnover to Enhance Survival in Pancreatic Cancer
There was a strong, statistically significant Pearson correlation (r = 0.504, p < 0.001) between survival time and length and frequency of DDW treatment.
https://pubmed.ncbi.nlm.nih.gov/33760674/
14. The effect of preliminary administration of water with reduced deuterium content on the growth of transplantable tumors in mice
It was found that water with reduced Deuterium content effectively inhibited the growth of the transplantable tumors under study, significantly reduced metastasis weight in mice with LLC and increased life-span in animals with transplantable UCC.
https://pubmed.ncbi.nlm.nih.gov/16715705/
15. The effect of the deuterium depleted water on the biological activity of the eukaryotic cells
We have shown that the deuterium depleted water considerably suppressed cancer cell lines amoeboid movement in vitro.
https://pubmed.ncbi.nlm.nih.gov/29773469/
16. Deuterium Depletion May Delay the Progression of Prostate Cancer
The 91 retrospectively evaluated patients achieved an MST of 11.02 years, despite the fact that 46 of them suffered from distant metastasis. In the two monitored patients, drop of PSA level correlated with the DDW intake. In summary, D-depletion prolonged MST in patients with PC. The method proved to be safe thus its integration in the PC cure as an adjuvant or complementary therapy would be considered.
https://www.scirp.org/journal/paperinformation?paperid=7799
17. Effects of deuterium depleted water alone and in combination of known chemotherapeutic agents on different tumor cells
In conclusion, deuterium depletion inhibits tumor cell proliferation and decreases their migration. Furthermore, in combination with known anti-cancer drugs deuterium depletion had a synergistic effects. Based on these results deuterium depletion therapy could be used alone as well as in combination with different chemotherapeutic treatment protocols in the clinics. Further studies are needed to confirm the effects of combination therapy in animal experiments as well as in human clinical trials.
18. A retrospective study of survival in breast cancer patients undergoing deuterium depletion in addition to conventional therapies
Conclusion
D-depletion may be a highly effective therapy both in the
treatment of early-stage or advanced breast cancer and
in preventing disease recurrence. The method is safe and
innocuous; preclinical toxicology studies [20], prospective
and retrospective clinical trials [14, 18] confirmed that
absolutely no adverse events occurred during long-term
application of DDW at a wide concentration range of 25 to
125 ppm. We conclude that D-depletion offers additional
benefits to conventional therapy and can be integrated
into standard treatment regimens for breast cancer
19. Deuterium-depleted water selectively inhibits nasopharyngeal carcinoma cell proliferation in vitro
Results: DDW with deuterium concentrations of 100, 75 and 50 ppm significantly suppressed the cell proliferation (P<0.05) and lowered colony formation capacity and invasiveness of the NPC cells (P<0.01). Western blotting demonstrated a down-regulated expression of PCNA in the cells by DDW. DDW also caused obvious cell cycle arrest in the NPC cells with reduced cells in S phase and significantly increased cells in G(1) phase (P<0.05). Rather than causing growth inhibition, DDW promoted the growth of normal control MC3T3-E1 cells.
Conclusion: DDW possesses selective biological effects to inhibit the proliferation of NPC cells in vitro, suggesting the potential of DDW as a novel nontoxic adjuvant therapeutic agent in antitumor therapy.
https://pubmed.ncbi.nlm.nih.gov/23076171/
List of Publications:
Podcasts/Videos
- Deuterium and Health with Dr. Laszlo Boros, Dr. Que Collins, and Dr. Anne Cooper. https://www.youtube.com/watch?v=1V4cJvogjVY
- Deuterium Depletion: The Most Powerful Health Hack You’ve Never Heard Of with Que Collins and Laszlo Boros- https://www.lukestorey.com/lifestylistpodcast/deuterium-depletion-the-most-powerful-health-hack-youve-never-heard-of-w/-dr-que-collins-dr-laszlo-boros-165. https://www.youtube.com/watch?v=eEjobyXZJ_8
- Dr Laszlo Boros on Deuterium Depletion for Optimal Health. https://www.youtube.com/watch?v=IPVxexMNw7k
- Dr Laszlo Boros on Deuterium Depletion for Optimal Health-Kriben Govender (Honours Degree in Food Science and Technology) has a mind-blowing conversation with Dr Laszlo Boros from The Deuterium Depletion Centre on the dangers of excess deuterium and strategies to naturally deplete deuterium from your body for optimal health. We discuss the impact of deuterium on our mitochondria, gut and microbiome. https://podcast.nourishmeorganics.com.au/dr-laszlo-boros-on-deuterium-depletion-for-optimal-health
- Top Cancer Expert: Could This Help Against Cancer?- Dr Gabor Somalyai and Andre Chafee- 2024. https://www.youtube.com/watch?v=v0lh274Y8oM
- Cancer, Ketosis, and Deuterium with Dr Gabor Somlyai, PhD! https://www.youtube.com/watch?v=SH0g4rhYxKM
- Nourish Vermont 2018 | Dr. László Boros | Heavy hydrogen (deuterium) in nutritional medicine- https://www.youtube.com/watch?v=z7SjlJy1xME&t=4057s
Info Websites
https://www.drinklitewater.com/pages/media#media-kit
Papers
HOW TO DEVELOP A DEUTERIUM DEPLETED DIET; Do’s and Dont’s
Long-term survival rates of cancer patients achieved by deuterium depletion as an adjuvant treatment in spinal astrocytic glioma, carcinoma mammae and melanoma malignum-The cases presented show that, after the start of DDW consumption, progression could be avoided, and a symptom-free status with good quality of life could be maintained for decades. These results are consistent with earlier findings with different tumor types including breast, lung, pancreas, and prostate cancer, and CLL, when integration of deuterium depletion into conventional therapies resulted in a severalfold increase in median survival time.
https://jclinmedcasereports.com/articles/OJCMCR-2121.pdf
Long-term survival rates of cancer patients achieved by deuterium depletion as an adjuvant treatment in spinal astrocytic glioma, carcinoma mammae and melanoma malignum
https://www.mdpi.com/2227-9059/11/7/1989/pdf
A Preliminary Study Indicating Improvement in the Median
Survival Time of Glioblastoma Multiforme Patients by the
Application of Deuterium Depletion in Combination with
Conventional Therapy
Mexico and Deuterium Trends:
Lung cancer in Mexico: findings from the Global Burden of Disease Study, 1990-2016
chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.scielo.org.mx/pdf/spm/v61n3/0036-3634-spm-61-03-240.pdf
Map of hydrogen isotopes (isoscapes)
USA and Deuterium Trends
Stable isotope ratios of tap water in the contiguous United States
https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2006WR005186
Books:
Here’s why your body’s deuterium levels are probably too high (above 130 ppm):
- Deuterium levels in the water we drink and breathe have been rising for about the past 11,700 years
- Eating carbohydrates and processed foods elevates deuterium in our bodies
- When we get insufficient sleep, sunlight, cold exposure, or exercise, or breathe improperly, we accumulate deuterium
There are at least four key ways deuterium can negatively affect the body:
- Creating unhealthy growth
- Altering three-dimensional structures
- Slowing down chemical reactions (the kinetic isotope effect)
- Damaging mitochondria and breaking ATP nanomotors
1- Deuterium and Growth
Plants, children, and young animals use deuterium for healthy natural growth. But the issue that should concern you is how deuterium can create unhealthy growth. In adulthood, having high levels of deuterium also fosters an environment of growth in your body. Growth “outward” is obesity, and growth in the wrong places in the body is cancerous growth.
2- Three-Dimensional Structures and Deuterium
When you accumulate a lot of deuterium in your body, your cells will begin to use deuterium in place of regular hydrogen. Remember, deuterium can easily go anywhere normal hydrogen goes, in a chemical formula or reaction. Unfortunately, that’s how deuterium alters the 3D shape and the function of molecules in the body.
Here are just a few examples of 3D biomolecules that won’t function correctly when deuterated:
- Cholesterol
- Hormones
- Neurotransmitters
- Cellular receptors
Yes, all of those molecules play critical roles in the body. That’s another reason why deuterium accumulation factors into a lot of severe disease states that seem unrelated, but in fact have a root cause in common.
3- The Kinetic Isotope Effect
Your body uses plain hydrogen (one proton, one electron) in many different chemical reactions. When your body substitutes deuterium in place of hydrogen, these reactions are slowed down because of the kinetic isotope effect (KIE). Due to the KIE, many normal reactions involving carbon and hydrogen will be slowed down by 6–10 times in the body when your deuterium levels are high.
Here are examples of what can happen:
- Enzymatic reactions are slowed down
- Neurotransmitter release and reuptake are slowed down
- Cellular division and repair are slowed down
- Liver metabolism is slowed down
Proper timing at the molecular level is critical to your health. Slowing down reactions is a recipe for disaster. The kinetic isotope effect also causes quantum tunneling, putting deuterium in more places it shouldn’t be.
4- Mitochondrial Health and Deuterium
Energy production is impacted by deuterium, too. Our bodies contain trillions of mitochondria. To produce energy and enable your cells to function correctly, tiny motors inside your mitochondria must spin at 6000–9000 rpm.
The ATP synthase nanomotors use electrons to attract protons (hydrogen ions) then create adenosine triphosphate (ATP, an energy storage molecule), carbon dioxide, and metabolic water.
When deuterium enters the mitochondria in place of hydrogen, the heavy hydrogen can literally break your nanomotors. Broken nanomotors means less energy production and big trouble.
5- Deuterium Depletion and Health
Deuterium depletion means actively lowering your deuterium levels by making changes to diet, lifestyle, and the type of water you drink.
There are several ways to lower deuterium for better health and wellness:
- Fasting and dry fasting lower deuterium
- Ketogenic diet, seasonal ketogenic diet, and low-carb high-fat diets lower deuterium
- Quality sleep in darkness lowers deuterium
- Sunlight, cold exposure, breathwork, and exercise help lower deuterium
- Drinking deuterium-depleted water (DDW) lowers deuterium
6- Deuterium Depletion: Wellness vs. Therapy
Here’s why you may want to deplete deuterium for wellness:
- For better cognition
- To improve energy levels
- To enhance athletic performance and recovery
- To increase your metabolic rate
- To prevent disease
Healthy people typically only need to focus on depleting their deuterium for several months. Then it becomes easier to maintain low levels.
If you are currently fighting disease, deuterium depletion therapy is extraordinarily safe and works in conjunction with conventional standards of care.
It isn’t a new experimental drug with scary side-effects — it’s merely a way of removing something unhealthy from your body.
There are several different ways to deplete deuterium. For best results, you need to implement more than one method.
7- Fasting, Dry Fasting, Keto, and LCHF Deplete Deuterium
You’re probably already familiar with fasting and all the associated health benefits. You may not know that fasting works in part because of deuterium depletion. When you aren’t consuming food, your body switches to fat for fuel. No food means no deuterium coming from carbohydrates, and fat burning means deuterium depletion. The reason fat burning depletes deuterium is because for every kilogram of fat we burn, our body creates 1.1 kg of metabolic water (using hydrogen from the fat, plus oxygen). Metabolic water is created inside our cells and is naturally deuterium-depleted.
Dry fasting is also a highly effective way to deplete deuterium, but it isn’t appropriate for beginners. A dry fast is a fast with no food, water, or liquids. When you dry fast, your body produces metabolic water for hydration. f you dry fast without enough experience, or for too long, you will get dehydrated.
The ketogenic diet or a low-carb high-fat diet is an easy and safe way to deplete deuterium without necessarily fasting. As you reduce your carbohydrate consumption and adapt to using fat as fuel, your deuterium levels will decrease.
8- Sleep, Sunlight, Cold, Oxygen, and Exercise Deplete Deuterium
Sleeping deeply in a dark room helps you deplete deuterium. If you don’t sleep well, you probably have high deuterium levels because you are not depleting enough deuterium at night.
Sunlight also helps our bodies deplete deuterium. The more sun exposure you receive, the easier you can deplete deuterium. That’s one reason why sunlight reduces all-cause mortality, including time-adjusted deaths by cancer, even melanoma.
That’s also why you may want to adopt a seasonal eating pattern and eat locally. Plant photosynthesis in times and places where UV is high tends to create more deuterium in food (carbohydrates), but our bodies can also eliminate it more easily when we get a lot of sunlight.
If you eat out of schedule with the seasons, like consuming bananas in Massachusetts in January, you will increase your body’s deuterium levels.
Cold exposure is another great way to deplete deuterium, especially if you are getting less sun. Cold thermogenesis increases mitochondrial activity through the loosely coupled pathway, activates brown adipose tissue, and liberates fat stores.
Exercise helps deplete deuterium because it increases your metabolic rate, fat burning, and respiration.
Breathing properly — oxygenating tissues — is necessary to deplete deuterium because the aerobic pathways require a lot of oxygen to work.
To enhance deuterium depletion improve your sleep, get exposure to sunlight and cold, exercise regularly, and do breathwork.
These practices probably aren’t enough to lower high deuterium levels (over 130 ppm) all by themselves, but they will improve your results.
If you have low deuterium levels (under 130 ppm), you’ll be able to stay that way by improving depletion mechanisms.
9- Deuterium-Depleted Water or DDW
Deuterium depleted water (DDW) is a powerful tool for deuterium depletion.
You can deplete deuterium without using DDW, but it is useful in the following circumstances:
- If you need to get your deuterium levels lower ASAP
- If you continue eating foods that are higher in deuterium (processed foods and carbohydrates)
- If your body is unable to deplete deuterium on its own due to illness
Technically any water with under 155 ppm deuterium is depleted, but for real impact, you want therapeutic DDW — 125 ppm or less.
For deuterium depletion, drink 1–1.5 liters or more of DDW per day and limit or avoid other liquids.
For wellness, your DDW consumption should stay between approximately 85–125 ppm.
You can dilute Qlarivia with Aquafina as follows:
- 8 parts regular water + 1 part 25ppm Water = 140 ppm DDW
- 4 parts regular water + 1 part 25ppm Water = 129 ppm DDW
- 3 parts regular water + 1 part 25ppm Water = 122 ppm DDW
- 2 parts regular water + 1 part 25ppm Water = 111 ppm DDW
- 1 part regular water + 1 part 25ppm Water = 90ppm DDW
Some healthy people online are using 25 ppm DDW as a biohack for wellness.
That is a bad idea because they could get their levels lower using less drastic measures. Save the 25 ppm for worst case scenarios.
Again: don’t go below ~90 ppm DDW unless you are a serious decease or can’t achieve acceptable levels using other means.